{"id":315845,"date":"2025-06-03T14:40:54","date_gmt":"2025-06-03T14:40:54","guid":{"rendered":"https:\/\/www.pierluigibove.com\/2025\/06\/03\/genetics-that-is-changing-urology-prof-pierluigi-bove-explains-the-clinical-value-of-prostatype\/"},"modified":"2026-01-13T11:48:32","modified_gmt":"2026-01-13T11:48:32","slug":"genetics-that-is-changing-urology-prof-pierluigi-bove-explains-the-clinical-value-of-prostatype","status":"publish","type":"post","link":"https:\/\/www.pierluigibove.com\/en\/2025\/06\/03\/genetics-that-is-changing-urology-prof-pierluigi-bove-explains-the-clinical-value-of-prostatype\/","title":{"rendered":"Genetics that is changing urology: Prof. Pierluigi Bove explains the clinical value of Prostatype\u00ae"},"content":{"rendered":"\n<p class=\"has-vivid-cyan-blue-color has-text-color has-link-color has-medium-font-size wp-elements-e45060b5b19312baf0481f007bd801e2 wp-block-paragraph\">Prostatype genetic test. Genetics that is changing urology: Prof. Pierluigi Bove explains the clinical value of Prostatype\u00ae <\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">In recent years, genetics has begun to play a central role in personalized medicine. In particular, urology has proven to be one of the most fertile areas for integrating advanced genetic tools into prognostic and therapeutic decision-making. A concrete, timely example is the use of the Prostatype\u00ae genetic test, discussed in a recent interview published by an international outlet with Professor Pierluigi Bove, MD, urology specialist, Associate Professor of Urology at the University of Rome Tor Vergata, and Head of U.R.M.I. \u2013 Robotic and Minimally Invasive Urology at the Policlinico University Hospital of the same university.  <\/p>\n\n\n\n<p class=\"has-vivid-cyan-blue-color has-text-color has-link-color has-medium-font-size wp-elements-6b1662657a8e9f030897d828b0e903cf wp-block-paragraph\">A new paradigm for prostate cancer prognosis<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u201cGenetics is giving us a series of innovative approaches that can improve diagnosis and prognosis, and also help us understand which treatment may be best for the patient.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">The introduction of the Prostatype\u00ae test is an important step in this direction. <br>The Prostatype\u00ae Test was introduced\u2014also thanks to Prof. Bove\u2019s clinical and research contribution\u2014within the UOC of Medical Genetics at Policlinico Tor Vergata, where Prof. Bove teaches. It is a next-generation test, developed in Sweden at the prestigious Karolinska Institute, which makes it possible to identify specific tumor genes in patients already diagnosed with prostate cancer, in order to predict its evolution with a high degree of accuracy. <\/p>\n\n\n\n<p class=\"has-vivid-cyan-blue-color has-text-color has-link-color has-medium-font-size wp-elements-68e32d4926df5f9bfc422b5689d697eb wp-block-paragraph\">How the Prostatype\u00ae test works<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u201cProstatype is certainly among the most advanced tests worldwide. Making it available to patients is very important.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u201cWhen it comes to prostate cancer, genetics allows us to identify different tumor variants, understand what type of disease we are dealing with, and its level of aggressiveness.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">The test is performed on biopsy samples that have already been collected for histological examination. The genetic analysis focuses on the expression of three genes\u2014<strong>IGFBP3,<\/strong> <strong>F3,<\/strong> and <strong>VGLL3<\/strong>\u2014which are combined, through a sophisticated algorithm, with other clinical data from the patient. The result is a numerical indicator that expresses the risk of prostate-cancer mortality in the ten years following diagnosis.  <\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u201cThis is therefore a very important <strong>prognostic test,<\/strong> because it allows us to identify tumors that may require immediate treatment, distinguishing them from those that, instead, may only require active surveillance.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u201cProstatype expresses the risk of death within 10 years from diagnosis through a numerical value. This risk is classified as low up to 2.3%, intermediate between 2.3% and 25%, and high between 25% and 80%.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"631\" src=\"https:\/\/www.pierluigibove.com\/wp-content\/uploads\/2025\/06\/Pierluigi-Bove-Urologist-Blog-Post-Genetics-that-is-changing-urology-featured-2-1024x631.jpg\" alt=\"\" class=\"wp-image-315878\" srcset=\"https:\/\/www.pierluigibove.com\/wp-content\/uploads\/2025\/06\/Pierluigi-Bove-Urologist-Blog-Post-Genetics-that-is-changing-urology-featured-2-980x604.jpg 980w, https:\/\/www.pierluigibove.com\/wp-content\/uploads\/2025\/06\/Pierluigi-Bove-Urologist-Blog-Post-Genetics-that-is-changing-urology-featured-2-480x296.jpg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1024px, 100vw\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"has-vivid-cyan-blue-color has-text-color has-link-color has-medium-font-size wp-elements-bb4e94887cbeff42b497ff46b4b08290 wp-block-paragraph\">Moving beyond simple \u201cactive surveillance\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">According to guidelines, patients with a low-aggressiveness cancer should be managed with active surveillance. This means that intervention can be postponed. The patient is still followed with PSA testing every 3 months, or a new biopsy is performed one year after diagnosis.  <\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u201cDuring this time, however, the tumor can evolve and become aggressive. Prostatype is what allows us to know this from the very first assessment after diagnosis.\u201d<\/p>\n\n\n\n<p class=\"has-vivid-cyan-blue-color has-text-color has-link-color has-medium-font-size wp-elements-70d601baad1c53cbb83fe216fbb51cd7 wp-block-paragraph\">Toward a more personalized, more human medicine<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">The practical advantage of the test lies in the ability to adapt the therapeutic strategy to the tumor\u2019s real aggressiveness, <strong>helping patients and clinicians make a more informed decision about treatment options.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u201cThe advantages of Prostatype? The traditional method requires constant PSA monitoring which, if it rises, would force the patient to go through the entire diagnostic pathway again, and therefore a long series of tests. With Prostatype\u2019s indications, instead, it may be possible to intervene earlier, limiting oncologic and functional harm.\u201d<\/p>\n\n\n\n<p class=\"has-vivid-cyan-blue-color has-text-color has-link-color has-medium-font-size wp-elements-61d7f7ceedcb206523a5bb4163f0f86f wp-block-paragraph\">Who the test is for, and what it can offer<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">On the test\u2019s clinical use, Professor Bove specified: \u201cThe ideal patient for Prostatype is someone who has received a diagnosis of prostate cancer with low or intermediate risk. With the traditional method, these patients would be placed on an active surveillance protocol, which obliges them to undergo many tests over time, with all the psychological consequences that can follow. Prostatype provides an initial answer that can help bring the patient more peace of mind, whatever the test outcome, before offering a therapeutic chance.\u201d<\/p>\n\n\n\n<p class=\"has-vivid-cyan-blue-color has-text-color has-link-color has-medium-font-size wp-elements-51e424d2eb362ecee63726788e3b6c9e wp-block-paragraph\">A leading clinical project<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">The test, developed after over 15 years of research at the Karolinska Institute, is now available in only a few centers in Europe. \u201cApart from us, for now it is used only in Spain.\u201d <\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">Clinical adoption in Italy began with a major procurement at Policlinico Universitario Tor Vergata, with a value of about 1.8 million Swedish kronor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u201cWe are still at the beginning, but I am confident that this approach will soon spread across Italy, perhaps with some additional awareness initiatives.\u201d<\/p>\n\n\n\n<p class=\"has-vivid-cyan-blue-color has-text-color has-link-color has-medium-font-size wp-elements-7a639c392d7c29d619007bf8c31b4f4a wp-block-paragraph\">A safer future for oncology patients<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">Prostatype\u00ae is a clear signal of the change underway: genetic tools, predictive algorithms, and precision medicine are reshaping how prostate cancer is approached, placing the patient truly at the center of the therapeutic pathway.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\ud83d\udd17\u202f<strong>Link to the LinkedIn article:<\/strong> <a href=\"https:\/\/www.linkedin.com\/posts\/prostatypegenomicsab_prostatype-genomics-newsletter-april-2025-activity-7328337604494417920-O-CL\/?utm_source=share&amp;utm_medium=member_ios&amp;rcm=ACoAAAUS0-cB53usMFmv0Zvk86S4jBiKgt83ids\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">The clinical use of Prostatype \u2013 prognostic gene test is increasing in Italy<\/a><br>\ud83d\udd17\u202f<strong>Read the full interview with Professor Bove:<\/strong> <a href=\"https:\/\/lnkd.in\/dV-3etub\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">https:\/\/lnkd.in\/dV-3etub<\/a><br>\ud83d\udd17 <strong>Link to the Italian Prostatype\u00ae website:<\/strong> <a href=\"https:\/\/lnkd.in\/dVWy5KHv\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">https:\/\/lnkd.in\/dVWy5KHv<\/a><br>\ud83d\udd17 <strong>Link to the URMI page (Robotic and Minimally Invasive Urology) at Policlinico Tor Vergata: <\/strong><a href=\"https:\/\/www.pierluigibove.com\/en\/u-r-m-i\/\">https:\/\/www.pierluigibove.com\/urologia-robotica-mini-invasiva\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prostatype genetic test. Genetics that is changing urology: Prof. Pierluigi Bove explains the clinical value of Prostatype\u00ae In recent years, genetics has begun to play a central role in personalized medicine. In particular, urology has proven to be one of the most fertile areas for integrating advanced genetic tools into prognostic and therapeutic decision-making. A [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":315877,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"off","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[57,59,1,60],"tags":[],"class_list":["post-315845","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-genetics","category-prostate","category-uncategorized","category-urology"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.1 (Yoast SEO v27.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Prof. Pierluigi Bove explains the clinical value of Prostatype<\/title>\n<meta name=\"description\" content=\"Prof. Pierluigi Bove explains how the Prostatype genetic test is reshaping prostate cancer prognosis through a more precise, patient-specific approach.\" \/>\n<meta name=\"robots\" content=\"index, follow, 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